Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.
Identifieur interne : 000454 ( Main/Exploration ); précédent : 000453; suivant : 000455Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.
Auteurs : J P Teifke [Allemagne] ; R. Klopfleisch ; A. Globig ; E. Starick ; B. Hoffmann ; P U Wolf ; M. Beer ; T C Mettenleiter ; T C HarderSource :
- Veterinary pathology [ 0300-9858 ] ; 2007.
Descripteurs français
- KwdFr :
- ARN viral (), ARN viral (génétique), Allemagne (épidémiologie), Animaux, Anseriformes, Cervelet (anatomopathologie), Cervelet (virologie), Coeur (virologie), Flambées de maladies (médecine vétérinaire), Foie (anatomopathologie), Foie (virologie), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (virologie), Grippe chez les oiseaux (épidémiologie), Immunohistochimie (médecine vétérinaire), Maladies des oiseaux (anatomopathologie), Maladies des oiseaux (virologie), Maladies des oiseaux (épidémiologie), Myocarde (anatomopathologie), Océans et mers, Pancréas (anatomopathologie), Pancréas (virologie), RT-PCR (médecine vétérinaire), Sous-type H5N1 du virus de la grippe A (croissance et développement), Sous-type H5N1 du virus de la grippe A (génétique).
- MESH :
- anatomopathologie : Cervelet, Foie, Grippe chez les oiseaux, Maladies des oiseaux, Myocarde, Pancréas.
- croissance et développement : Sous-type H5N1 du virus de la grippe A.
- génétique : ARN viral, Sous-type H5N1 du virus de la grippe A.
- médecine vétérinaire : Flambées de maladies, Immunohistochimie, RT-PCR.
- virologie : Cervelet, Coeur, Foie, Grippe chez les oiseaux, Maladies des oiseaux, Pancréas.
- épidémiologie : Allemagne, Grippe chez les oiseaux, Maladies des oiseaux.
- ARN viral, Animaux, Anseriformes, Océans et mers.
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- Animals, Anseriformes, Bird Diseases (epidemiology), Bird Diseases (pathology), Bird Diseases (virology), Cerebellum (pathology), Cerebellum (virology), Disease Outbreaks (veterinary), Germany (epidemiology), Heart (virology), Immunohistochemistry (veterinary), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (growth & development), Influenza in Birds (epidemiology), Influenza in Birds (pathology), Influenza in Birds (virology), Liver (pathology), Liver (virology), Myocardium (pathology), Oceans and Seas, Pancreas (pathology), Pancreas (virology), RNA, Viral (chemistry), RNA, Viral (genetics), Reverse Transcriptase Polymerase Chain Reaction (veterinary).
- MESH :
- chemical , chemistry : RNA, Viral.
- geographic , epidemiology : Germany.
- epidemiology : Bird Diseases, Influenza in Birds.
- genetics : Influenza A Virus, H5N1 Subtype, RNA, Viral.
- growth & development : Influenza A Virus, H5N1 Subtype.
- pathology : Bird Diseases, Cerebellum, Influenza in Birds, Liver, Myocardium, Pancreas.
- veterinary : Disease Outbreaks, Immunohistochemistry, Reverse Transcriptase Polymerase Chain Reaction.
- virology : Bird Diseases, Cerebellum, Heart, Influenza in Birds, Liver, Pancreas.
- Animals, Anseriformes, Oceans and Seas.
Abstract
Mortality in wild aquatic birds due to infection with highly pathogenic avian influenza viruses (HPAIV) is a rare event. During the recent outbreak of highly pathogenic avian influenza in Germany, mortality due to H5N1 HPAIV was observed among mute and whooper swans as part of a rapid spread of this virus. In contrast to earlier reports, swans appeared to be highly susceptible and represented the mainly affected species. We report gross and histopathology and distribution of influenza virus antigen in mute and whooper swans that died after natural infection with H5N1 HPAIV. At necropsy, the most reliable lesions were multifocal hemorrhagic necrosis in the pancreas, pulmonary congestion and edema, and subepicardial hemorrhages. Major histologic lesions were acute pancreatic necrosis, multifocal necrotizing hepatitis, and lymphoplasmacytic encephalitis with neuronal necrosis. Adrenals displayed consistently scattered cortical and medullary necrosis. In spleen and Peyer's patches, mild lymphocyte necrosis was present. Immunohistochemical demonstration of HPAIV nucleoprotein in pancreas, adrenals, liver, and brain was strongly consistent with histologic lesions. In the brain, a large number of neurons and glial cells, especially Purkinje cells, showed immunostaining. Occasionally, ependymal cells of the spinal cord were also positive. In the lungs, influenza virus antigen was identified in a few endothelial cells but not within pneumocytes. The infection of the central nervous system supports the view that the neurotropism of H5N1 HPAIV leads to nervous disturbances with loss of orientation. More investigations are necessary to clarify the mechanisms of the final circulatory failure, lung edema, and rapid death of the swans.
DOI: 10.1354/vp.44-2-137
PubMed: 17317790
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.</title><author><name sortKey="Teifke, J P" sort="Teifke, J P" uniqKey="Teifke J" first="J P" last="Teifke">J P Teifke</name><affiliation wicri:level="1"><nlm:affiliation>Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems, Germany. Jens.Teifke@fli.bund.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Klopfleisch, R" sort="Klopfleisch, R" uniqKey="Klopfleisch R" first="R" last="Klopfleisch">R. Klopfleisch</name></author><author><name sortKey="Globig, A" sort="Globig, A" uniqKey="Globig A" first="A" last="Globig">A. Globig</name></author><author><name sortKey="Starick, E" sort="Starick, E" uniqKey="Starick E" first="E" last="Starick">E. Starick</name></author><author><name sortKey="Hoffmann, B" sort="Hoffmann, B" uniqKey="Hoffmann B" first="B" last="Hoffmann">B. Hoffmann</name></author><author><name sortKey="Wolf, P U" sort="Wolf, P U" uniqKey="Wolf P" first="P U" last="Wolf">P U Wolf</name></author><author><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name></author><author><name sortKey="Mettenleiter, T C" sort="Mettenleiter, T C" uniqKey="Mettenleiter T" first="T C" last="Mettenleiter">T C Mettenleiter</name></author><author><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:17317790</idno><idno type="pmid">17317790</idno><idno type="doi">10.1354/vp.44-2-137</idno><idno type="wicri:Area/Main/Corpus">000476</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000476</idno><idno type="wicri:Area/Main/Curation">000476</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000476</idno><idno type="wicri:Area/Main/Exploration">000476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.</title><author><name sortKey="Teifke, J P" sort="Teifke, J P" uniqKey="Teifke J" first="J P" last="Teifke">J P Teifke</name><affiliation wicri:level="1"><nlm:affiliation>Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems, Germany. Jens.Teifke@fli.bund.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems</wicri:regionArea><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion><wicri:noRegion>17493 Greifswald-Insel Riems</wicri:noRegion></affiliation></author><author><name sortKey="Klopfleisch, R" sort="Klopfleisch, R" uniqKey="Klopfleisch R" first="R" last="Klopfleisch">R. Klopfleisch</name></author><author><name sortKey="Globig, A" sort="Globig, A" uniqKey="Globig A" first="A" last="Globig">A. Globig</name></author><author><name sortKey="Starick, E" sort="Starick, E" uniqKey="Starick E" first="E" last="Starick">E. Starick</name></author><author><name sortKey="Hoffmann, B" sort="Hoffmann, B" uniqKey="Hoffmann B" first="B" last="Hoffmann">B. Hoffmann</name></author><author><name sortKey="Wolf, P U" sort="Wolf, P U" uniqKey="Wolf P" first="P U" last="Wolf">P U Wolf</name></author><author><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name></author><author><name sortKey="Mettenleiter, T C" sort="Mettenleiter, T C" uniqKey="Mettenleiter T" first="T C" last="Mettenleiter">T C Mettenleiter</name></author><author><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name></author></analytic><series><title level="j">Veterinary pathology</title><idno type="ISSN">0300-9858</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anseriformes</term><term>Bird Diseases (epidemiology)</term><term>Bird Diseases (pathology)</term><term>Bird Diseases (virology)</term><term>Cerebellum (pathology)</term><term>Cerebellum (virology)</term><term>Disease Outbreaks (veterinary)</term><term>Germany (epidemiology)</term><term>Heart (virology)</term><term>Immunohistochemistry (veterinary)</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (growth & development)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (pathology)</term><term>Influenza in Birds (virology)</term><term>Liver (pathology)</term><term>Liver (virology)</term><term>Myocardium (pathology)</term><term>Oceans and Seas</term><term>Pancreas (pathology)</term><term>Pancreas (virology)</term><term>RNA, Viral (chemistry)</term><term>RNA, Viral (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction (veterinary)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral ()</term><term>ARN viral (génétique)</term><term>Allemagne (épidémiologie)</term><term>Animaux</term><term>Anseriformes</term><term>Cervelet (anatomopathologie)</term><term>Cervelet (virologie)</term><term>Coeur (virologie)</term><term>Flambées de maladies (médecine vétérinaire)</term><term>Foie (anatomopathologie)</term><term>Foie (virologie)</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (virologie)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Immunohistochimie (médecine vétérinaire)</term><term>Maladies des oiseaux (anatomopathologie)</term><term>Maladies des oiseaux (virologie)</term><term>Maladies des oiseaux (épidémiologie)</term><term>Myocarde (anatomopathologie)</term><term>Océans et mers</term><term>Pancréas (anatomopathologie)</term><term>Pancréas (virologie)</term><term>RT-PCR (médecine vétérinaire)</term><term>Sous-type H5N1 du virus de la grippe A (croissance et développement)</term><term>Sous-type H5N1 du virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cervelet</term><term>Foie</term><term>Grippe chez les oiseaux</term><term>Maladies des oiseaux</term><term>Myocarde</term><term>Pancréas</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Bird Diseases</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Influenza A Virus, H5N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term><term>Sous-type H5N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Flambées de maladies</term><term>Immunohistochimie</term><term>RT-PCR</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bird Diseases</term><term>Cerebellum</term><term>Influenza in Birds</term><term>Liver</term><term>Myocardium</term><term>Pancreas</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term><term>Immunohistochemistry</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cervelet</term><term>Coeur</term><term>Foie</term><term>Grippe chez les oiseaux</term><term>Maladies des oiseaux</term><term>Pancréas</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bird Diseases</term><term>Cerebellum</term><term>Heart</term><term>Influenza in Birds</term><term>Liver</term><term>Pancreas</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe chez les oiseaux</term><term>Maladies des oiseaux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Anseriformes</term><term>Oceans and Seas</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Animaux</term><term>Anseriformes</term><term>Océans et mers</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mortality in wild aquatic birds due to infection with highly pathogenic avian influenza viruses (HPAIV) is a rare event. During the recent outbreak of highly pathogenic avian influenza in Germany, mortality due to H5N1 HPAIV was observed among mute and whooper swans as part of a rapid spread of this virus. In contrast to earlier reports, swans appeared to be highly susceptible and represented the mainly affected species. We report gross and histopathology and distribution of influenza virus antigen in mute and whooper swans that died after natural infection with H5N1 HPAIV. At necropsy, the most reliable lesions were multifocal hemorrhagic necrosis in the pancreas, pulmonary congestion and edema, and subepicardial hemorrhages. Major histologic lesions were acute pancreatic necrosis, multifocal necrotizing hepatitis, and lymphoplasmacytic encephalitis with neuronal necrosis. Adrenals displayed consistently scattered cortical and medullary necrosis. In spleen and Peyer's patches, mild lymphocyte necrosis was present. Immunohistochemical demonstration of HPAIV nucleoprotein in pancreas, adrenals, liver, and brain was strongly consistent with histologic lesions. In the brain, a large number of neurons and glial cells, especially Purkinje cells, showed immunostaining. Occasionally, ependymal cells of the spinal cord were also positive. In the lungs, influenza virus antigen was identified in a few endothelial cells but not within pneumocytes. The infection of the central nervous system supports the view that the neurotropism of H5N1 HPAIV leads to nervous disturbances with loss of orientation. More investigations are necessary to clarify the mechanisms of the final circulatory failure, lung edema, and rapid death of the swans.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17317790</PMID><DateCompleted><Year>2007</Year><Month>05</Month><Day>08</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0300-9858</ISSN><JournalIssue CitedMedium="Print"><Volume>44</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Veterinary pathology</Title><ISOAbbreviation>Vet. Pathol.</ISOAbbreviation></Journal><ArticleTitle>Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.</ArticleTitle><Pagination><MedlinePgn>137-43</MedlinePgn></Pagination><Abstract><AbstractText>Mortality in wild aquatic birds due to infection with highly pathogenic avian influenza viruses (HPAIV) is a rare event. During the recent outbreak of highly pathogenic avian influenza in Germany, mortality due to H5N1 HPAIV was observed among mute and whooper swans as part of a rapid spread of this virus. In contrast to earlier reports, swans appeared to be highly susceptible and represented the mainly affected species. We report gross and histopathology and distribution of influenza virus antigen in mute and whooper swans that died after natural infection with H5N1 HPAIV. At necropsy, the most reliable lesions were multifocal hemorrhagic necrosis in the pancreas, pulmonary congestion and edema, and subepicardial hemorrhages. Major histologic lesions were acute pancreatic necrosis, multifocal necrotizing hepatitis, and lymphoplasmacytic encephalitis with neuronal necrosis. Adrenals displayed consistently scattered cortical and medullary necrosis. In spleen and Peyer's patches, mild lymphocyte necrosis was present. Immunohistochemical demonstration of HPAIV nucleoprotein in pancreas, adrenals, liver, and brain was strongly consistent with histologic lesions. In the brain, a large number of neurons and glial cells, especially Purkinje cells, showed immunostaining. Occasionally, ependymal cells of the spinal cord were also positive. In the lungs, influenza virus antigen was identified in a few endothelial cells but not within pneumocytes. The infection of the central nervous system supports the view that the neurotropism of H5N1 HPAIV leads to nervous disturbances with loss of orientation. More investigations are necessary to clarify the mechanisms of the final circulatory failure, lung edema, and rapid death of the swans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Teifke</LastName><ForeName>J P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Federal Research Institute for Animal Health, Boddenblick 5A, 17493 Greifswald-Insel Riems, Germany. Jens.Teifke@fli.bund.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klopfleisch</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Globig</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Starick</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>P U</ForeName><Initials>PU</Initials></Author><Author ValidYN="Y"><LastName>Beer</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mettenleiter</LastName><ForeName>T C</ForeName><Initials>TC</Initials></Author><Author ValidYN="Y"><LastName>Harder</LastName><ForeName>T C</ForeName><Initials>TC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Vet Pathol</MedlineTA><NlmUniqueID>0312020</NlmUniqueID><ISSNLinking>0300-9858</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046090" MajorTopicYN="Y">Anseriformes</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001715" MajorTopicYN="N">Bird Diseases</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002531" MajorTopicYN="N">Cerebellum</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006321" MajorTopicYN="N">Heart</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009792" MajorTopicYN="N">Oceans and Seas</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010179" MajorTopicYN="N">Pancreas</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>2</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>5</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>2</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17317790</ArticleId><ArticleId IdType="pii">44/2/137</ArticleId><ArticleId IdType="doi">10.1354/vp.44-2-137</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Beer, M" sort="Beer, M" uniqKey="Beer M" first="M" last="Beer">M. Beer</name><name sortKey="Globig, A" sort="Globig, A" uniqKey="Globig A" first="A" last="Globig">A. Globig</name><name sortKey="Harder, T C" sort="Harder, T C" uniqKey="Harder T" first="T C" last="Harder">T C Harder</name><name sortKey="Hoffmann, B" sort="Hoffmann, B" uniqKey="Hoffmann B" first="B" last="Hoffmann">B. Hoffmann</name><name sortKey="Klopfleisch, R" sort="Klopfleisch, R" uniqKey="Klopfleisch R" first="R" last="Klopfleisch">R. Klopfleisch</name><name sortKey="Mettenleiter, T C" sort="Mettenleiter, T C" uniqKey="Mettenleiter T" first="T C" last="Mettenleiter">T C Mettenleiter</name><name sortKey="Starick, E" sort="Starick, E" uniqKey="Starick E" first="E" last="Starick">E. Starick</name><name sortKey="Wolf, P U" sort="Wolf, P U" uniqKey="Wolf P" first="P U" last="Wolf">P U Wolf</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Teifke, J P" sort="Teifke, J P" uniqKey="Teifke J" first="J P" last="Teifke">J P Teifke</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeAllemagneV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000454 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000454 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= GrippeAllemagneV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:17317790
|texte= Pathology of natural infections by H5N1 highly pathogenic avian influenza virus in mute (Cygnus olor) and whooper (Cygnus cygnus) swans.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:17317790" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV3
| This area was generated with Dilib version V0.6.35. |  |